LP16112-2
Dicoumarol
Active
Description
Dicoumarol (International Nonproprietary Name) or dicumarol (United States Adopted Name) is an anticoagulant that functions as a Vitamin K antagonist (similar to warfarin, for which it was the inspiration). It is also used in biochemical experiments as an inhibitor of reductases.
Dicoumarol is a natural chemical substance of combinded plant and fungal origin. It is a derivative of coumarin, a substance made by plants that does not itself affect coagulation, but which is (classically) transformed in mouldy feeds by a number of species of fungi into active dicoumarol. Dicoumarol does affect coagulation, and was discovered in mouldy wet sweet-clover hay, as the agent of a naturally occurring bleeding disease in cattle.
It is given only orally, and it acts within two days.
Mechanism of action : it is a competitive inhibitor of Vitamin K preventing the formation of prothrombin. Administration of Vitamin K is the antidote for dicoumarol toxicity. Follow-up is done by measuring the prothrombin time (PT).
Uses: Used along with heparin for the treatment of deep venous thrombosis
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Source: Wikipedia,
Wikipedia
Basic Part Properties
- Part Name
- Dicoumarol
- Part Display Name
- Dicoumarol
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2000-05-04
- Construct for LOINC Short Name
- Dicoumarol
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 双香豆素 Synonyms: 双杀鼠灵; |
| fr-CA | French (Canada) | Dicoumarol |
| et-EE | Estonian (Estonia) | Dikumarool |
| es-ES | Spanish (Spain) | Dicumarol |
| it-IT | Italian (Italy) | Dicoumarol |
| tr-TR | Turkish (Turkey) | Dikumarol |
| ru-RU | Russian (Russian Federation) | Дикумарол |
| nl-NL | Dutch (Netherlands) | dicoumarol |
| fr-BE | French (Belgium) | Dicoumarol |
| fr-FR | French (France) | Dicoumarol |
| el-GR | Greek (Greece) | Δικουμαρόλη Synonyms: Δικουμαρόλη |
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