Version 2.77

Descriptions

Ofloxacin is a synthetic chemotherapeutic antibiotic of the fluoroquinolone drug class considered to be a second-generation fluoroquinolone. The original brand, Floxin, has been discontinued by the manufacturer in the United States in 2009, though generic equivalents continue to be available.

Oral and I.V. Floxin is not licensed by the FDA for use in children due to the risk of serious reversible and irreversible injury to the musculoskeletal system. Ofloxacin (and its derivatives) has also been associated with a few isolated reports of unexplained pediatric fatalities. Children (those under 18) are also at an increased risk of bone, joint, or tendon toxicities.

In the adult population ofloxacin is limited to the treatment of proven serious and life threatening bacterial infections such as:
Acute bacterial exacerbations of chronic bronchitis
Community-acquired pneumonia
Uncomplicated skin and skin structure infections
Nongonococcal urethritis and cervicitis
Mixed Infections of the urethra and cervix
Acute pelvic inflammatory disease
Uncomplicated cystitis
Complicated urinary tract infections
Prostatitis
Acute, uncomplicated urethral and cervical gonorrhea
Mycobacterial infections Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Ofloxacin (Wikipedia)

A synthetic fluoroquinolone (FLUOROQUINOLONES) antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION. Source: National Library of Medicine, MeSH 2006

Basic Part Properties

Part Display Name
Ofloxacin
Part Type
Component (Describes the core component or analyte measured)
Created On
2000-05-04
Construct for LOINC Short Name
Ofloxacin

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Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) 氧氟沙星
Synonyms: 吡啶羧酶
fr-CA French (Canada) Ofloxacine
et-EE Estonian (Estonia) Ofloksatsiin
es-ES Spanish (Spain) Ofloxacina
it-IT Italian (Italy) Ofloxacina
tr-TR Turkish (Turkey) Oflokzasin
ru-RU Russian (Russian Federation) Офлоксацин
nl-NL Dutch (Netherlands) ofloxacine
fr-BE French (Belgium) Ofloxacine