Version 2.80

Descriptions

Probenecid is a uricosuric drug, primarily used in treating gout or hyperuricemia, that increases uric acid removal in the urine. Probenecid also decreases the renal excretion of some drugs. In one study, probenecid was shown to more than double a patient's exposure to oseltamivir (trade name Tamiflu), an antiviral drug used to combat influenza. This is significant because nations are currently stockpiling oseltamivir in anticipation of an influenza pandemic, and the drug is in short supply. During World War II, probenecid was used to extend limited supplies of penicillin, and is still currently used to increase antibiotic concentrations in serious infections. It has also found use as a masking agent by athletes attempting to get away with using performance enhancing drugs. In the kidneys it is filtered at the glomerulus, secreted in the proximal tubule and reabsorbed in the distal tubule. Probenecid's exact mechanism of action in the kidneys' nephrons is unknown. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia , Probenecid (Wikipedia)

The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy. Source: National Library of Medicine, MeSH 2006

Basic Part Properties

Part Name
Probenecid
Part Display Name
Probenecid
Part Type
Component (Describes the core component or analyte measured)
Created On
2000-05-04
Construct for LOINC Short Name
Probenecid

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
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Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) 丙磺舒
Synonyms: 二丙苯磺胺;倍尼密特;对羟基正丙基;羧苯尼散;羧苯磺胺
es-ES Spanish (Spain) Probenecid
it-IT Italian (Italy) Probenecid
et-EE Estonian (Estonia) Probenetsiid
tr-TR Turkish (Turkey) Probenesid
ru-RU Russian (Russian Federation) Пробенецид
fr-BE French (Belgium) Probénécide
fr-CA French (Canada) Probénécide
nl-NL Dutch (Netherlands) probenecide
el-GR Greek (Greece) Προβενεσίδη
Synonyms: Προβενεσίδη