LP16428-2
Hemoglobin F
Active
Descriptions
Hemoglobin F is used to screen for fetal-to-maternal hemorrrhage. The presence of fetal red cells in the maternal circulation may be identified by use of the acid elution principle first described by Kleihauer, Brown, and Betke, or by several modifications. Very small volumes of red cells commonly escape from the fetal intravascular compartment across the placental barrier into the maternal intervillous space. Source: Regenstrief Institute
Fetal hemoglobin, or foetal haemoglobin, (also hemoglobin F or HbF) is the main oxygen transport protein in the fetus during the last seven months of development in the uterus and in the newborn until roughly 6 months old. Functionally, fetal hemoglobin differs most from adult hemoglobin in that it is able to bind oxygen with greater affinity than the adult form, giving the developing fetus better access to oxygen from the mother's bloodstream.
In newborns, fetal hemoglobin is nearly completely replaced by adult hemoglobin by approximately 6 months postnatally. In adults, fetal hemoglobin production can be reactivated pharmacologically, which is useful in the treatment of diseases such as sickle-cell disease.
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Source: Wikipedia, Wikipedia
Reference Information
| Type | Source | Reference |
|---|---|---|
| Article | Regenstrief Institute | Fibach E, Flow cytometric analysis of fetal hemoglobin in RBC and their precursors. Fetal Hemoglobin |
Basic Part Properties
- Part Display Name
- Hemoglobin F
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2000-05-04
- Construct for LOINC Short Name
- Hgb F
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 血红蛋白 F Synonyms: HbF; |
| fr-CA | French (Canada) | Hémoglobine F |
| et-EE | Estonian (Estonia) | Hemoglobiin F |
| es-ES | Spanish (Spain) | Hemoglobina fetal |
| it-IT | Italian (Italy) | Emoglobina F |
| tr-TR | Turkish (Turkey) | Hemoglobin F |
| ru-RU | Russian (Russian Federation) | Гемоглобин F |
| nl-NL | Dutch (Netherlands) | hemoglobine F |
| fr-BE | French (Belgium) | Hémoglobine F Synonyms: HbF |
| pl-PL | Polish (Poland) | Hemoglobina F |
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