Version 2.77

Description

Histoplasmosis capsulatum is a dimorphic fungal pathogen with filamentous or yeast forms,depending on nutritional factors and temperature.The M antigen is a well-known glycoprotein used as a diagnostic antigen for acute histoplasmosis as it induces the first precipitins during disease. Monoclonal antibodies (mAbs) to the M antigen have been found to modify the pathogenesis of histoplasmosis.Given the shortcomings of current therapies, the administration of mAbs is being investigated. PMID: 22347215 The H band is less commonly seen than the M band and is indicative of chronic or severe acute infections with H capsulatum.

H. capsulatum is found in nature primarily as a saprophytic mold. The mold form is comprised of hyaline septate hyphae, which produce two different asexual reproduction structures, macroconidia and microconidia. The micronidia are believed to be responsible for disease propagation since their 2-6 µm size is well suited for disposition into the distal alveoli. Infection is typically acquired through inhalation of fungal propagules upon disturbances of contaminated soil or excreta. Environmental and genetic factors influence disease manifestations which can range from asymptomatic or mild influenza-like disease to a disseminated sepsis form. Manifestations depend on the magnitude of exposure, the host's immunological status and the virulence of the infective strain. Reactivation of latent infection can result in significant disease, particularly for immunosuppressed individuals. Despite the availability of potent antifungal drugs, nearly one in ten patients hospitalized with histoplasmosis dies. PMID: 17223625 Source: Regenstrief LOINC

Basic Part Properties

Part Display Name
Histoplasma capsulatum
Part Type
Component (Describes the core component or analyte measured)
Created On
2000-05-04
Construct for LOINC Short Name
H capsul

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP16650-1
ConceptMap translate
https://fhir.loinc.org/ConceptMap/$translate?system=http://loinc.org&code=LP16650-1

Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) 荚膜组织胞浆菌
Synonyms: 皮疽组织胞浆菌;美洲型组织胞浆菌;鼻疽性组织浆菌
fr-CA French (Canada) Histoplasma capsulatum
et-EE Estonian (Estonia) Histoplasma capsulatum
es-ES Spanish (Spain) Histoplasma capsulatum
it-IT Italian (Italy) Histoplasma capsulatum
tr-TR Turkish (Turkey) Histoplazma Kapsulatum
ru-RU Russian (Russian Federation) Histoplasma capsulatum
nl-NL Dutch (Netherlands) Histoplasma capsulatum
fr-BE French (Belgium) Histoplasma capsulatum