Version 2.78

Description

Keyhole limpet hemocyanin (KLH) is a large, multisubunit, oxygen-carrying, metalloprotein found in the hemolymph of the giant keyhole limpet, Megathura crenulata. KLH is being used in a variety of cancer vaccines, including non-Hodgkins lymphoma, cutaneous melanoma, breast and bladder cancer. These vaccines contain specific tumor-associated antigens conjugated to KLH to stimulate anti-tumor immune responses which can destroy tumor cells. KLH is very immunogenic, so assays to monitor humoral immune responses against KLH in human serum have been developed. An individual's humoral and cellular anti-KLH response is indicative for their immunocompetence (Grant et al. 2008, PMID: 18295445. Testing for anti-KLH antibodies may also be performed as a biomarker for vaccine-immunogenicity of KLH-containing and KLH-conjugated vaccines (Irfan et al. 2007, PMID: 17936425. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Keyhole limpet hemocyanin

Basic Part Properties

Part Display Name
Keyhole limpet hemocyanin
Part Type
Component (Describes the core component or analyte measured)
Created On
2013-01-14
Construct for LOINC Short Name
KLH

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP171884-2

Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) 钥孔戚血蓝蛋白
Synonyms: 钥孔血蓝素;钥孔血蓝蛋白;钥孔戚血蓝素;钥孔虫戚血兰素;钥孔傶血兰蛋白;血蓝蛋白;血兰蛋白;钉形贝血蓝蛋白;钥孔戚血青蛋白;钥孔戚血蓝质;keyhole limpet hemocyanin;KLH
es-ES Spanish (Spain) Hemocianina
it-IT Italian (Italy) Emocianina di Megathura crenulata
tr-TR Turkish (Turkey) Keyhole limpet hemosiyanin
ru-RU Russian (Russian Federation) Megathura crenulata гемоцианин
nl-NL Dutch (Netherlands) keyhole limpet hemocyanine