LP172766-0
induced neutrophil Ab.IgM
Active
Description
The drug interacts with the neutrophil causing a conformational change that reveals a previously hidden neutrophil membrane epitope. The immune system attacks this epitope - so the antibody is against the neutrophil, not the drug. Testing takes washed neutrophils (not the patient's neutrophils) and tests the patient's serum for antibodies against the neutrophils in the presence of the drug in question. Patient's serum is tested with and without the drug, and the test is positive when the difference (or ratio) of the two reaches a particular level. This is important because it is believed to be the cause of some forms of immune neutropenia and testing is usually done to assess the possibility that a given drug has caused the neutropenia. However stopping the drug usually reverses the neutropenia and may speak for itself. Flow cytometry is a common if not the most common way to test for this phenomenon. The culprit is mostly IgG antibodies, but IgM and IgA have also been implicated. Per a lab with much experience with these tests the presence of drug dependent antibodies against WBCs are very rare compared the analogous phenomena with platelets. For drugs other than quinine they find a positive WBC drug dependent antibody only once every 2-3 years. Source: Regenstrief Help
Basic Part Properties
- Part Name
- induced neutrophil Ab.IgM
- Part Display Name
- induced neutrophil IgM
- Part Type
- Suffix
- Created On
- 2013-03-27
- Construct for LOINC Short Name
- (neut) IgM
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 诱导型嗜中性粒细胞抗体.IgM Synonyms: 诱导型（诱导性、 |
| es-ES | Spanish (Spain) | Acs. IgM neutrófilos inducidos |
| it-IT | Italian (Italy) | Ab.IgM neutrofili indotti da |
| tr-TR | Turkish (Turkey) | uyarılmış nötrofil Ab.IgM |
| ru-RU | Russian (Russian Federation) | индуцированный нейтрофил Ат.IgM |
| nl-NL | Dutch (Netherlands) | geïnduceerd neutrofiel As.IgM |
| fr-FR | French (France) | Polynucléaires neutrophiles anticorps IgM induits |
| pl-PL | Polish (Poland) | indukowane Ab do neutrofilów.IgM |
| el-GR | Greek (Greece) | επαγόµενα αντισώματα ουδετερόφιλων.IgM Synonyms: επαγόµενα αντισώματα ουδετερόφιλων.IgM |
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