Version 2.78

Description

18 Beta-Glycyrrhetinic acid (GRA) is a major metabolite of glycyrrhizic acid (glycyrrhizin), which is obtained from licorice and licorice root. GRA inhibits 11 beta-hydroxysteroid dehydrogenase (11 beta OHSD) which in turn inhibits the conversion of active cortisol to inactive cortisone in the kidneys. This leads to high cortisol levels in the collecting duct of the kidney. Patients often have high blood pressure with a low renin and low aldosterone blood level. The increased amounts of cortisol binds to the unprotected, unspecific mineralocorticoid receptors and induce sodium and fluid retention, hypokalaemia, high blood pressure and inhibition of the renin-angiotensin-aldosterone system. Therefore licorice should not be given to patients with a known history of hypertension. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, 18 Beta-Glycyrrhetinic acid (GRA)

Basic Part Properties

Part Display Name
18-Beta glycyrrhetinate
Part Type
Component (Describes the core component or analyte measured)
Created On
2013-04-09
Construct for LOINC Short Name
GRA

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP172797-5
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Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) 18-Beta 甘草次酸
Synonyms: 18-Beta 甘草酸;18-Beta 甘草亭酸;18-Beta 氢琥珀酸甘草次酸;18-Beta 琥珀酰甘草亭酸;18-β 甘草次酸
es-ES Spanish (Spain) 18-Beta glicirrinato
it-IT Italian (Italy) 18 beta glicirretico acido
tr-TR Turkish (Turkey) 18-Beta glisirretinat
ru-RU Russian (Russian Federation) 18-Бета глицирретинат
nl-NL Dutch (Netherlands) 18-bèta-glycyrrhetinaat