LP173521-8
MAML2 11q21 gene rearrangements
Active
Description
Mucoepidermoid carcinomas (MEC) represent 5% of all salivary gland tumors and 20% of salivary malignancies. A portion of these carcinomas are associated with gene rearrangements involving the the C-terminal of mastermind-like gene 2 (MAML2) and either cAMP response element-binding protein (CREB)-regulated transcription coactivator 1 (CRTC1) or 3 (CRTC3). CTCR1-MAML2 fusion has been detected in 40-80% of primary salivary gland mucoepidermoid carcinomas. MECs positive for MAML2 fusions (CRTC1-MAML2 or CRTC3-MAML2) are associated with favorable clinicopathological tumor features, including lower patient age, a mild female predilection, a smaller tumor size, less frequent nodal metastasis, a lower clinical stage, a lower histological grade, and longer overall and disease-free survival. Source: Regenstrief LOINC, PMID: 23035786
Basic Part Properties
- Part Name
- MAML2 11q21 gene rearrangements
- Part Display Name
- MAML2 11q21 gene rearrangements
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2013-06-11
- Construct for LOINC Short Name
- MAML2 11q21
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | MAML2 11q21 基因重排 Synonyms: MAML2 11q21 基因重排（重组） |
| es-ES | Spanish (Spain) | Reordenamientos gen MAML2 11q21 |
| it-IT | Italian (Italy) | MAML2 11q21, riarrangiamenti genici |
| tr-TR | Turkish (Turkey) | MAML2 11q21 geni yeniden düzenleme |
| ru-RU | Russian (Russian Federation) | MAML2 11q21 ген перестройки |
| nl-NL | Dutch (Netherlands) | MAML2 11q21-genherschikkingen Synonyms: MAML2 11q21 gentranslocaties |
| fr-FR | French (France) | MAML2 gène 11q21 réarrangements |
| pl-PL | Polish (Poland) | MAML2 11q21 gen rearanżacje Synonyms: Rearanżacje genu MAML2 11q21 |
| el-GR | Greek (Greece) | Γονιδιακές αναδιατάξεις MAML2 11q21 Synonyms: Γονιδιακές αναδιατάξεις MAML2 11q21 |
LOINC Copyright
Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://