LP173614-1
P27
Active
Description
Cell cycle progression is regulated by cyclins and their cognate cyclin-dependent kinases (Cdks). P27 (Kip1) is a member of the Cip/Kip family of cyclin-dependent kinase inhibitors. P27 binds to and inhibits cyclinE-Cdk2, cyclinA-CDK2 and cyclinD1-CDK4 complex and enforce the G1 restriction point. It is a candidate tumor suppressor gene, and has been proposed to function as a possible mediator of TGF beta induced G1 arrest. P27 is up regulated in quiescent cells and in cells treated with cAMP and antimitogenic stimuli. P27 is regulated by phosphorylation on serine 10 (S10) and threonine 187 (T187). Phosphorylation by CDK2 on T187 results in ubiquitylation and degradation of p27; while phosphorylation by hKIS on S10 signals the nuclear export to the cytoplasm. Source: LOINC partner 1
Basic Part Properties
- Part Name
- P27
- Part Display Name
- P27
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2013-07-31
- Construct for LOINC Short Name
- P27
LOINC Terminology Service (API) using HL7® FHIR® Get Info
Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.
- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=LP173614-1
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | P27 Synonyms: Kip1; |
| it-IT | Italian (Italy) | P27 |
| ru-RU | Russian (Russian Federation) | P27 |
| es-ES | Spanish (Spain) | P27 |
| tr-TR | Turkish (Turkey) | P27 |
| nl-NL | Dutch (Netherlands) | p27 |
| el-GR | Greek (Greece) | P27 Synonyms: P27 |
LOINC Copyright
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