LP173633-1

Matrix metallopeptidase 2

Active

Descriptions

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Source: National Center for Biotechnology Information (NCBI) Gene, MMP

Matrix metalloproteinase-2 (MMP-2), a.k.a 72 kDa type IV collagenase or gelatinase A, is an enzyme that in humans is encoded by the MMP2 gene. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Mutations in the MMP2 gene are associated with Torg-Winchester syndrome, multicentric osteolysis and arthritis syndrome. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, MMP2

Basic Part Properties

Part Name

Matrix metallopeptidase 2

Part Display Name

Matrix metallopeptidase 2

Part Type

Component (Describes the core component or analyte measured)

Created On

2013-08-01

Construct for LOINC Short Name

MMP2

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