LP18072-6
Thiazides
Active
Descriptions
Thiazides are diuretics, a class of drug that promote water loss from the body. They inhibit Na +Cl - reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. The chemical structure of the original thiazide diuretics contained a thiazide ring system; the term is also used for drugs with a similar action that are not chemically thiazides, such as chlortalidone and metolazone. Thiazides are often used to treat hypertension. They are the recommended first-line treatment in the US (JNC VII) guidelines and a recommended treatment in the European (ESCESH) guidelines. They have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. They may cause vasodilation by desensitizing the vascular smooth muscle cells to calcium release induced by norepinephrine [PMID 15611360]. Side effects can include hypokalemia, increased serum cholesterol, and impotence. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia , Thiazides (Wikipedia)
Heterocyclic compounds with SULFUR and NITROGEN in the ring. This term commonly refers to the BENZOTHIADIAZINES that inhibit SODIUM-POTASSIUM-CHLORIDE SYMPORTERS and are used as DIURETICS. Source: National Library of Medicine, MeSH 2006
Basic Part Properties
- Part Name
- Thiazides
- Part Display Name
- Thiazides
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2000-05-04
- Construct for LOINC Short Name
- Thiazides
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 噻嗪类 Synonyms: 噻嗪化物; |
| es-ES | Spanish (Spain) | Tiazidas |
| it-IT | Italian (Italy) | Tiazidici |
| et-EE | Estonian (Estonia) | Tiasiidid |
| tr-TR | Turkish (Turkey) | Tiyazidler |
| ru-RU | Russian (Russian Federation) | Тиазиды |
| fr-BE | French (Belgium) | Thiazidiques |
| fr-CA | French (Canada) | Thiazidiques |
| nl-NL | Dutch (Netherlands) | thiaziden |
| el-GR | Greek (Greece) | Θειαζίδες Synonyms: Θειαζίδες |
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