LP18167-4
IgA.secretory
Active
Descriptions
Secretory IgA is a dimer with a special secretory component that protects it from proteolytic digestion. IgA protects the GI tract and other endothelial surfaces from infection IgA does not cross the placenta (for practical purposes) Source: Regenstrief Institute
IgA has two subclasses (IgA1 and IgA2) and can exist in a dimeric form called secretory IgA (sIgA). In its secretory form, IgA is the main immunoglobulin found in mucous secretions, including tears, saliva, colostrum and secretions from the genitourinary tract, gastrointestinal tract, prostate and respiratory epithelium. It is also found in small amounts in blood. The secretory component of sIgA protects the immunoglobulin from being degraded by proteolytic enzymes, thus sIgA can survive in the harsh gastrointestinal tract environment and provide protection against microbes that multiply in body secretions.
Decreased or absent IgA, termed selective IgA deficiency, can be a clinically significant immunodeficiency.
Neisseria gonorrhœae (which causes gonorrhea), Streptococcus pneumoniae, and Haemophilus influenzae type B all releases a protease which destroys IgA.
IgA nephropathy is caused by IgA deposits in the kidneys. It is not yet known why IgA deposits occur in this chronic disease. Some theories suggest an abnormality of the immune system results in these deposits.
Celiac disease involves IgA pathology due to the presence of IgA antiendomysial antibodies.
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Source: Wikipedia
, Wikipedia
Basic Part Properties
- Part Name
- IgA.secretory
- Part Display Name
- IgA.secretory
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2000-05-04
- Construct for LOINC Short Name
- SIgA
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | IgA.分泌型 Synonyms: SIgA; |
| es-ES | Spanish (Spain) | IgA secretora |
| it-IT | Italian (Italy) | IgA.secretorie |
| et-EE | Estonian (Estonia) | IgA.sekretoorne |
| tr-TR | Turkish (Turkey) | IgA.sekretuvar |
| ru-RU | Russian (Russian Federation) | IgA.секреторный |
| fr-BE | French (Belgium) | IgA.sécrétoire Synonyms: sIgA |
| fr-CA | French (Canada) | IgA.sécrétoire |
| nl-NL | Dutch (Netherlands) | IgA.secretoir |
| pl-PL | Polish (Poland) | Ig A.wydzielncza Synonyms: Wydzielnicza immunoglobulina A |
| el-GR | Greek (Greece) | IgA.εκκριτική Synonyms: IgA.εκκριτική |
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