Log In

Description

Peripheral deiodinase activity is the rate of conversion of circulating T4 to the biologically active T3 by monodeiodination. Changes in peripheral deiodinase activity may reflect conditions that are difficult to diagnose based on traditional thyroid function tests, such as non-thyroidal illness syndrome. PMID: 27375554

Estimated sum activity of peripheral deiodinases (GD) represents deiodination capacity, i.e. the maximal amount of T3 that can be formed from T4 in one second. SPINA-GD is calculated with GD = beta31 * (KM1 + [FT4]) * (1 + K30 * [TBG]) * [FT3] / (alpha31 * [FT4]) or GD = beta31 * (KM1 + [FT4]) * [TT3] / (alpha31 * [FT4]) from serum or plasma concentrations of free (FT3) or total (TT3) triiodothyronine and free (FT4) or total (TT4) thyroxine, and some constants (alpha31 = Dilution factor for T3: 0.026 l-1; beta31 = Clearance exponent for T3: 8e-6 sec-1; KM1 = Dissociation constant of type-1-deiodinase: 5e-7 mol/l; K30 = Dissociation constant T3-TBG: 2e9 l/mol) Source: Regenstrief LOINC

Basic Part Properties

Part Name
Peripheral deiodinase activity
Part Display Name
Peripheral deiodinase activity
Part Type
Component (Describes the core component or analyte measured)
Created On
2014-01-27
Construct for LOINC Short Name
Per deiod act

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP182358-4

Language Variants Get Info

TagLanguageTranslation
zh-CNChinese (China)外周脱碘酶活性
Synonyms: 外周去碘酶活性;外周脱碘酶活力;GD;脱碘能力;总脱碘酶活性;脱碘酶总活性;deiodination capacity;total deiodinase activity
es-ESSpanish (Spain)Actividad de la deiodinasa periférica
it-ITItalian (Italy)Attività deiodinasi periferica
fr-FRFrench (France)Déiodinase périphérique activité
el-GRGreek (Greece)Δραστικότητα περιφερικής δεϊωδινάσης
Synonyms: Δραστικότητα περιφερικής δεϊωδινάσης