LP182373-3
Aneuploid G1 phase cell population peak channel
Active
Descriptions
DNA index (DI), which is associated with DNA ploidy, is a reflection of the average amount of DNA in the tumor cells. The DI can be measured by flow cytometry or image cytometry, both of which result in a DNA ploidy histogram, where the channel number on the x-axis represents fluorescent intensity or optical density for the two methods, respectively. All cells with the same quantity of DNA form one peak on the histogram, and with a population of normal cells, the largest peak represents diploid cells in G1 of the cell cycle, and a smaller peak represents cells in G2/M-phase. When there is a mixed population of normal and tumor cells, two or more G1 peaks will be seen, one for the normal cells and one or more for the tumor cells. The DI is calculated by dividing the channel number of the tumor cell G1 peak by the channel number of the normal (diploid control) G1 peak. If the tumor cells are diploid, the DI is 1, and if the cells are aneuploid, the DI is greater than or less than 1. For example, tetraploid cells have a DI of 2 because they have twice as much DNA content as normal diploid cells, and hypodiploid tumor cells have a DI of <1. PMID: 24532190 Source: Regenstrief LOINC, PMID: 24532190
Cell cycle DNA analysis is used to quantify the number of cells in various phases of the cell cycle. Tumor cell cycle analysis can be used to assess the proliferative potential of the tumor, which in some types of cancer can be used as a prognostic indicator. G0 is a quiescent phase during which cells are metabolically active but no longer proliferate unless called on to do so by appropriate extracellular signals. The G1 phase is the interval between mitosis and start of DNA replication during which the cell is metabolically active and continuously grows but does not replicate its DNA. G1 is followed by the S phase, during which DNA replication occurs. G2 follows S, and during G2 the cell continues to grow and synthesize proteins in preparation for mitosis. The M phase of the cycle corresponds to mitosis, during which the cell divides. [NCBI Books: NBK9876] Source: Regenstrief LOINC, NCBI Books: NBK9876
Basic Part Properties
- Part Name
- Aneuploid G1 phase cell population peak channel
- Part Display Name
- Aneuploid G1 phase cell population peak channel
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2014-01-29
- Construct for LOINC Short Name
- Aneu G1 pop peak chan
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | pico población celuar aneuploide en fase G1 |
| it-IT | Italian (Italy) | Fase G1 popolazione cellulare aneuploide, canale di picco |
| tr-TR | Turkish (Turkey) | Aneuploid G1 fazı hücre popülasyonu tepe kanalı |
| nl-NL | Dutch (Netherlands) | aneuploïd G1 fase celpopulatie piek kanaal |
| zh-CN | Chinese (China) | 非整倍体 G1 期细胞总体峰值通道 Synonyms: 异倍体（非整倍体、 |
| fr-FR | French (France) | Cellules aneuploïdes en phase G1 pic de population |
| pl-PL | Polish (Poland) | Aneuploidalne komórki populacji w fazie G1, piki w kanale Synonyms: Piki w kanale dla populacji komórek aneuploidalnych w fazie G1 |
| el-GR | Greek (Greece) | Κανάλι αιχμής πληθυσμού ανευπλοειδών κυττάρων φάσης G1 Synonyms: Κανάλι αιχμής πληθυσμού ανευπλοειδών κυττάρων φάσης G1 |
LOINC Copyright
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