LP18354-8

CD38

Active

Descriptions

Found on early T- and B-cells, activated T- and B-cells and Plasma cells
Associated with Plasmacytic neoplasms; Peripheral T-cell lymphomas; some B-cell lymphomas Source: Regenstrief Institute

CD38 (cluster of differentiation 38) is a glycoprotein found on the surface of many immune cells (white blood cells), including CD4+, CD8+, B and natural killer cells. It is a marker of cell activation. The CD38 protein has been connected to HIV infection, leukemias, myelomas, solid tumors, type II diabetes mellitus and bone metabolism, as well as some genetically determined conditions. It has also been used as a prognostic marker in leukemia.

The gene encoding for CD38 is located on chromosome 4.

CD38 is a novel multifunctional ectoenzyme widely expressed in cells and tissues especially in leukocytes. CD38 also functions in cell adhesion, signal transduction and calcium signaling.

CD34 is found on hematopoietic stem cells (HSC) as well as many of the more differentiated cells that CD38 is found on, so one method for isolating HSC cells is by selecting for cells that express CD34 but do not express CD38. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, CD38

Basic Part Properties

Part Name

CD38

Part Display Name

CD38

Part Type

Component (Describes the core component or analyte measured)

Created On

2000-05-04

Construct for LOINC Short Name

CD38

LOINC Terminology Service (API) using HL7^® FHIR^® Get Info

Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.

CodeSystem lookup

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP18354-8

Language Variants Get Info

LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.