LP18425-6
4-Hydroxyphenylpyruvate
Active
Descriptions
4-Hydroxyphenylpyruvic acid is an intermediate in the metabolism of phenylalanine. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Wikipedia
4-Hydroxyphenylpyruvic acid (4-HPPA) is a keto acid. It is a product of the enzyme (R)-4-hydroxyphenyllactate dehydrogenase [EC 1.1.1.222] and is formed during tyrosine metabolism (KEGG). There are two isomers of HPPA, specifically 4HPPA and 3HPPA, of which 4HPPA is the most common. The enzyme 4-hydroxyphenylpyruvic acid dioxygenase (HPD) catalyzes the reaction of 4-hydroxyphenylpyruvic acid to homogentisic acid in the tyrosine catabolism pathway. A deficiency in the catalytic activity of HPD is known to lead to tyrosinemia type III, an autosomal recessive disorder characterized by elevated levels of blood tyrosine and massive excretion of tyrosine derivatives into urine. It has been shown that hawkinsinuria, an autosomal dominant disorder characterized by the excretion of 'hawkinsin,' may also be a result of HPD deficiency PMID: 11073718. Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database, Human Metabolome Database
Basic Part Properties
- Part Display Name
- 4-Hydroxyphenylpyruvate
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2000-05-04
- Construct for LOINC Short Name
- 4OH-phenylpyruvate
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 4-羟基苯丙酮酸 Synonyms: 4HPP; |
| fr-CA | French (Canada) | 4-hydroxyphénylpyruvate |
| et-EE | Estonian (Estonia) | 4-hüdroksüfenüülpüruvaat |
| es-ES | Spanish (Spain) | 4-Hidroxifenilpiruvato |
| it-IT | Italian (Italy) | 4-Idrossifenilpiruvato |
| tr-TR | Turkish (Turkey) | 4-Hidroksifenilpiruvat |
| ru-RU | Russian (Russian Federation) | 4-Гидроксифенилпируват |
| nl-NL | Dutch (Netherlands) | 4-hydroxyfenylpyruvaat Synonyms: 4-hydroxyfenylpyruvaat |
| fr-BE | French (Belgium) | 4-hydroxyphénylpyruvate |
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