LP184367-3
INS gene
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Descriptions
The INS gene encodes the preproinsulin precursor of insulin. Diseases associated with alterations of the INS gene include insulin autoimmune syndrome, insulin-dependent diabetes mellitus type 2 (IDDM2), neonatal diabetes mellitus (NDM), and maturity-onset diabetes of the young, type 10 (MODY 10). [OMIM:176730] Copyright OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University. Source: Online Mendelian Inheritance in Man®, INS gene
The INS gene (insulin) [HGNC Gene ID:6081] is located on chromosome 11p15.5. After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010] [NCBI Gene ID:3630] Source: National Center for Biotechnology Information (NCBI) Gene
Basic Part Properties
- Part Name
- INS gene
- Part Display Name
- INS gene
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2014-07-10
- Construct for LOINC Short Name
- INS
LOINC Terminology Service (API) using HL7® FHIR® Get Info
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | INS 基因 Synonyms: Insulin; |
| es-ES | Spanish (Spain) | Gen INS |
| it-IT | Italian (Italy) | INS, gene Synonyms: Gene INS |
| tr-TR | Turkish (Turkey) | INS geni |
| nl-NL | Dutch (Netherlands) | INS-gen Synonyms: INS gen |
| fr-FR | French (France) | INS gène |
| pl-PL | Polish (Poland) | INS gen Synonyms: Gen INS |
| el-GR | Greek (Greece) | Γονίδιο INS Synonyms: Γονίδιο INS |
LOINC Copyright
Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://