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Description

The CDKN1B gene (cyclin-dependent kinase inhibitor 1B (p27, Kip1)) [HGNC Gene ID:1785] is located on chromosome 12p13.1-p12. This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). [provided by RefSeq, Apr 2014] [NCBI Gene ID:1027] Source: National Center for Biotechnology Information (NCBI) Gene

Basic Part Properties

Part Name
CDKN1B gene
Part Display Name
CDKN1B gene
Part Type
Component (Describes the core component or analyte measured)
Created On
2014-07-10
Construct for LOINC Short Name
CDKN1B

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP184368-1

Language Variants Get Info

TagLanguageTranslation
zh-CNChinese (China)CDKN1B 基因
Synonyms: 细胞周期蛋白依赖性激酶抑制剂 1B (p27, Kip1);周期蛋白依赖激酶抑制剂 1B (p27, Kip1);细胞周期蛋白依赖性激酶抑制因子 1B (p27, Kip1);细胞周期蛋白依赖性激酶抑制剂 1B;周期蛋白依赖激酶抑制剂 1B;细胞周期蛋白依赖性激酶抑制因子 1B;Cyclin-dependent kinase inhibitor 1B (p27, Kip1);Cyclin-dependent kinase inhibitor 1B;CDKN1B;CDKN4;KIP1;MEN1B;MEN4
es-ESSpanish (Spain)Gen CDKN1B
it-ITItalian (Italy)CDKN1B, gene
Synonyms: Gene CDKN1B
tr-TRTurkish (Turkey)CDKN1B geni
nl-NLDutch (Netherlands)CDKN1B-gen
Synonyms: CDKN1B gen
fr-FRFrench (France)CDKN1B gène
pl-PLPolish (Poland)CDKN1B gen
Synonyms: Gen CDKN1B
el-GRGreek (Greece)Γονίδιο CDKN1B
Synonyms: Γονίδιο CDKN1B