LP18509-7
Interleukin 1 beta
Active
Descriptions
Interleukin 1, beta, also known as IL1B, is a cytokine protein which in humans is encoded by the IL1B gene. IL-1β precursor is cleaved by caspase 1 (interleukin 1 beta convertase). Cytosolic thiol protease cleaves the product to form mature IL-1β.
A number of studies associate the gene with susceptibility to schizophrenia
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Source: Wikipedia, Wikipedia
The Interleukins belong to the family termed cytokines. They are peptides used by immune and inflammatory cells to communicate and control cell operations. The cytokines have some similar actions to the Growth Factors but Growth Factors regulate proliferation of non-immune cells. Interleukin 1b is a 17,500 molecular weight peptide derived primarily from macrophages, fibroblasts, endothelial cells, and B cells. The major target cells are T and B cells, Fibroblasts, and Hepatocytes and it has pyrogenic activity. Interleukin 1b shares a receptor with Interleukin 1a although they are significantly different structurally. Interleukin 1b promotes antigen specific immune responses, inflammation, secretion, Colony Stimulating Factors, proteoglycanase, collagenase, and gelatinase activity, acute phase response, and cartilage resorption. Interleukin 1b increases accumulation of cell-associated and extracellular arachadonic acid, and induces release of Interleukin 6. Source: Inter Science Institute, Inter Science Institute
Basic Part Properties
- Part Display Name
- Interleukin 1 beta
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2000-05-04
- Construct for LOINC Short Name
- Il1Beta
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- CodeSystem lookup
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 白细胞介素 1 Beta Synonyms: IL-1B; |
| fr-CA | French (Canada) | Interleukine-1 bêta |
| et-EE | Estonian (Estonia) | Interleukiin 1 beeta |
| es-ES | Spanish (Spain) | Interleuquina 1 beta |
| it-IT | Italian (Italy) | Interleuchina 1 beta |
| tr-TR | Turkish (Turkey) | İnterlökin 1 beta |
| ru-RU | Russian (Russian Federation) | Интерлейкин 1 бета |
| nl-NL | Dutch (Netherlands) | interleukine 1 bèta |
| fr-BE | French (Belgium) | Interleukine-1 béta Synonyms: IL 1-béta |
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