LP185946-3

AXIN2 gene

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Description

The AXIN2 gene (axin 2) [HGNC Gene ID:904] is located on chromosome 17q24.1. The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008] [NCBI Gene ID:8313] Source: National Center for Biotechnology Information (NCBI) Gene

Basic Part Properties

Part Name

AXIN2 gene

Part Display Name

AXIN2 gene

Part Type

Component (Describes the core component or analyte measured)

Created On

2014-09-17

Construct for LOINC Short Name

AXIN2

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