Version 2.77

Description

Matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) is a type of mass spectrometry (MS). MALDI-TOF MS consists of three primary steps: 1) mixing the sample with an organic matrix, which provides a scaffolding and also protons for the ionization process; 2) applying a laser to the matrix, which absorbs energy from the laser and releases it into the sample, which causes the sample to desorb and form singly charged ions; and 3) using a flight tube to analyze the mass of the ions, ultimately resulting in a mass spectrum in which the mass-to-charge is plotted against signal intensity. MALDI-TOF is a soft ionization technique, meaning that molecules remain relatively intact during ionization. Because of this property, MALDI-TOF can be used for protein analysis; in contrast, older MS techniques cause extensive protein fragmentation and therefore cannot be used for this purpose. One application of MALDI-TOF is in clinical microbiology; compared to traditional methods, MALDI-TOF is faster and more accurate in identifying specific microorganisms. PMID: 23824373 Source: Regenstrief LOINC, PMID: 23824373

Basic Part Properties

Part Display Name
MS.MALDI-TOF
Part Type
Method (Describes the method by which the test was performed)
Created On
2014-10-17
Construct for LOINC Short Name
MS.MALDI-TOF

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CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP186074-3

Language Variants Get Info

Tag Language Translation
nl-NL Dutch (Netherlands) MALDI-TOF
Synonyms: massaspectometrie; Malditof
zh-CN Chinese (China) MS.MALDI-TOF
Synonyms: 基质辅助激光解吸/电离飞行时间质谱;基质辅助激光解吸电离飞行时间质谱;基质辅助激光解吸飞行时间质谱;基质辅助激光解析电离飞行时间质谱;Matrix-Assisted Laser Desorption/ Ionization Time of Flight Mass Spectrometry;MALDI-TOF-MS;Matrix-assisted laser desorption ionization–time of flight
es-ES Spanish (Spain) MS.MALDI-TOF
it-IT Italian (Italy) MS.MALDI-TOF
pl-PL Polish (Poland) spektrometria mas.MALDI-TOF