LP188415-6
Sheep prion protein codon 141
Active
Description
Scrapie is a fatal, degenerative disease affecting the central nervous system of sheep and goats. It is in the same class of diseases as BSE in cattle and Chronic Wasting Disease in elk and deer. Transmission of the classical scrapie agent is not completely understood but apparently healthy sheep infected with the agent can transmit disease. The infecting agent or prion is a mal-formed version (PrPsc ) of a normal protein (PrP) found in all animals. The malformation of the normal prion proteins occurs when they are exposed to the mal-formed version of the protein. The normal prion proteins may be more or less susceptible to malformation when they are exposed to the mal-formed protein based on their genetic makeup. Resistance or susceptibility has been linked to the presence of certain amino acids at various locations within the normal protein. Genotyping determines the amino acids present at specific locations or codons in the prion protein. These are reported as a pair of one character amino acid codes such as RR, RH, QQ, etc. This testing does not diagnosis Scrapie, but is an important tool for selecting genetically resistant animals for breeding and eradication. Codons associated with susceptibility/resistance to scrapie include codon 112, 136, 141, 154 and 171. Codon 141 codes for either phenylalanine (F) or leucine (L). The presence of F at codon 141 has been associated with increased susceptibility to Nor98 or an atypical form of scrapie. Source: American Association of Veterinary Laboratory Diagnosticians
Basic Part Properties
- Part Name
- Sheep prion protein codon 141
- Part Display Name
- Sheep prion protein codon 141
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2014-12-22
- Construct for LOINC Short Name
- Sheep PrP codon 141
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 绵羊朊蛋白密码子 141 Synonyms: 绵羊朊蛋白（朊病毒蛋白）密码子 141 |
| it-IT | Italian (Italy) | Pecora, proteina prionica codone 141 |
| tr-TR | Turkish (Turkey) | Koyun prion proteini kodon 141 |
| es-ES | Spanish (Spain) | proteína priónica en oveja, codon 141 |
| nl-NL | Dutch (Netherlands) | schapen prionproteïne codon 141 |
| pl-PL | Polish (Poland) | Białko prionowe owcy kodon 141 |
| el-GR | Greek (Greece) | Κωδικόνιο πρωτεΐνης πριόν προβάτου 141 Synonyms: Κωδικόνιο πρωτεΐνης πριόν προβάτου 141 |
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