LP188417-2
Sheep prion protein codon 136
Active
Description
Scrapie is a fatal, degenerative disease affecting the central nervous system of sheep and goats. It is in the same class of diseases as BSE in cattle and Chronic Wasting Disease in elk and deer. Transmission of the classical scrapie agent is not completely understood but apparently healthy sheep infected with the agent can transmit disease. The infecting agent or prion is a mal-formed version (PrPsc ) of a normal protein (PrP) found in all animals. The malformation of the normal prion proteins occurs when they are exposed to the mal-formed version of the protein. The normal prion proteins may be more or less susceptible to malformation when they are exposed to the mal-formed protein based on their genetic makeup. Resistance or susceptibility has been linked to the presence of certain amino acids at various locations within the normal protein. Genotyping determines the amino acids present at specific locations or codons in the prion protein. These are reported as a pair of one character amino acid codes such as RR, RH, QQ, etc. This testing does not diagnosis Scrapie, but is an important tool for selecting genetically resistant animals for breeding and eradication. Codons associated with susceptibility/resistance to scrapie include codon 112, 136, 141, 154 and 171. Codon 136 codes for either alanine (A), valine (V) or threonine (T). The presence of A at codon 136 has been associated with increased resistance to scrapie. The presence of V at codon 136 has been associated with increased susceptibility to scrapie. The presence of T at codon 136 has not been associated with scrapie resistance or susceptibility. Source: American Association of Veterinary Laboratory Diagnosticians
Basic Part Properties
- Part Display Name
- Sheep prion protein codon 136
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2014-12-22
- Construct for LOINC Short Name
- Sheep PrP codon 136
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 绵羊朊蛋白密码子 136 Synonyms: 绵羊朊蛋白（朊病毒蛋白）密码子 136 |
| es-ES | Spanish (Spain) | proteína priónica en oveja, codon 136 |
| it-IT | Italian (Italy) | Pecora, proteina prionica codone 136 |
| tr-TR | Turkish (Turkey) | Koyun prion proteini kodon 136 |
| nl-NL | Dutch (Netherlands) | schapen prionproteïne codon 136 |
| pl-PL | Polish (Poland) | Białko prionowe owcy kodon 136 |
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