LP190644-7
Thrombin activatable fibrinolysis inhibitor
Active
Description
TAFI (Thrombin Activatable Fibrinolysis Inhibitor) is a glycoprotein of a molecular weight of approximately 60,000 daltons and it belongs to the metalloprotease family, synthesized in the liver, and circulates in blood as a proenzyme without biological activity. TAFI is also called procarboxypeptidase U (CPU), procarboxypeptidase R (CPR), and plasma procarboxypeptidase B (CPB), and provides an essential link between fibrinolysis and coagulation cascade. Activated TAFI protects the fibrin clot against lysis. Defects in thrombin generation directly impact the protection of clots against lysis, thus defects in activation of TAFI may add to the severity of bleeding disorders. On the other hand, an increased activation of TAFI due to an increased rate of thrombin generation, may lead to thrombotic disorders. TAFI may also have an important function in the regulation of inflammation, wound healing and blood pressure. PMID: 15015228 PMID: 17008302 Elevated TAFI levels may form a mild risk factor for venous thrombosis. PMID: 10779431 Source: Regenstrief LOINC, PMID: 15015228
Basic Part Properties
- Part Name
- Thrombin activatable fibrinolysis inhibitor
- Part Display Name
- Thrombin activatable fibrinolysis inhibitor
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2015-04-22
- Construct for LOINC Short Name
- TAFI
LOINC Terminology Service (API) using HL7® FHIR® Get Info
Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 凝血酶激活的纤溶抑制物 Synonyms: 凝血酶激活的纤溶（纤维蛋白溶解）抑制物（抑制剂、 |
| es-ES | Spanish (Spain) | Inhibidor tisular del activador del plasminógeno |
| it-IT | Italian (Italy) | Inibitore della fibrinolisi attivabile dalla trombina Synonyms: TAFI |
| tr-TR | Turkish (Turkey) | Trombin aktiveedebilen fibrinoliz inhibitörü |
| nl-NL | Dutch (Netherlands) | trombine activeerbare fibrinolyse inhibitor |
| fr-FR | French (France) | Inhibiteur de fibrinolyse activable par la thrombine |
| el-GR | Greek (Greece) | Ενεργοποιούμενος από τη θρομβίνη αναστολέας της ινωδόλυσης Synonyms: Ενεργοποιούμενος από τη θρομβίνη αναστολέας της ινωδόλυσης |
LOINC Copyright
Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://