LP190800-5
Cells.MYC gene rearrangements
Active
Description
The MYC gene (v-myc avian myelocytomatosis viral oncogene homolog) [HGNC Gene ID:7553] is located on chromosome 8q24.21. The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008] [NCBI Gene ID:4609] Source: National Center for Biotechnology Information (NCBI) Gene
Basic Part Properties
- Part Display Name
- Cells.MYC gene rearrangements
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2015-05-06
- Construct for LOINC Short Name
- Cells.MYC rearr
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 细胞.MYC 基因重排 Synonyms: 细胞.MYC 基因重排（重组） |
| es-ES | Spanish (Spain) | Reordenamientos del gen MYC |
| it-IT | Italian (Italy) | Cellue.riarrangiamenti del gene MYC Synonyms: Riarrangiamenti del proto-oncogene MYC |
| tr-TR | Turkish (Turkey) | Hücreler.MYC geni yeniden düzenleme |
| nl-NL | Dutch (Netherlands) | cellen.MYC-genherschikking Synonyms: cellen.MYC gen translocaties |
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