LP190802-1
Cells.ALK gene rearrangements
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Description
The ALK gene (anaplastic lymphoma receptor tyrosine kinase) [HGNC Gene ID: 427] is located on chromosome 2p23. This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011] [NCBI Gene ID: 238] Source: National Center for Biotechnology Information (NCBI) Gene
Basic Part Properties
- Part Display Name
- Cells.ALK gene rearrangements
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2015-05-06
- Construct for LOINC Short Name
- Cells.ALK rearr
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- CodeSystem lookup
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 细胞.ALK 基因重排 Synonyms: 细胞.ALK 基因重排（重组） |
| es-ES | Spanish (Spain) | Reordenamiento del gen ALK |
| it-IT | Italian (Italy) | Cellule. Riarrangiamenti del gene ALK |
| tr-TR | Turkish (Turkey) | Hücreler.ALK geni yeniden düzenleme |
| nl-NL | Dutch (Netherlands) | cellen.ALK-genherschikking Synonyms: cellen.ALK gen translocaties |
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