LP19279-6

Donath Landsteiner

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Description

Landsteiner and Wiener used blood from a monkey (Macacus rhesus) to immunize rabbits and guinea pigs in order to define new antibody specificities. One of the antibodies they produced appeared to have the same specificity as a human antibody found in several woman who had stillborn fetuses. Consequently, the antibodies were named anti-Rh for rhesus. However, as early as 1942 it was known that the rabbit/guinea pig and human antibodies could not be the same. When the guinea pig antibody was used to test Rh+ and Rh negative cord blood cells (as defined by the human antibody) all samples were reactive. The guinea pig antibody was given the name "D-like". Then Race and Sanger found two women whose antibodies could be absorbed by Rh negative red cells and which appeared to be similar to the "D-like" antibody from animals. Following further studies by Levine the "D-like" name was changed to LW in honor of Landsteiner and Wiener. Source: Serum, Cells and Rare Fluid Exchange, Donath Landsteiner

Basic Part Properties

Part Name

Donath Landsteiner

Part Display Name

Donath Landsteiner

Part Type

Component (Describes the core component or analyte measured)

Created On

2000-05-04

Construct for LOINC Short Name

D-L

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