LP19506-2
CMKBR5 gene
Active
Description
The CMKBR5 gene (chemokine (C-C motif) receptor 5 (gene/pseudogene)) gene is located on chromosome 3p21.31. This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] [NCBI Gene ID:1234] Source: National Center for Biotechnology Information (NCBI) Gene
Basic Part Properties
- Part Name
- CMKBR5 gene
- Part Display Name
- CMKBR5 gene
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2000-05-04
- Construct for LOINC Short Name
- CMKBR5 gene
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | CMKBR5 基因 Synonyms: chemokine (C-C motif) receptor 5 (gene/pseudogene); |
| es-ES | Spanish (Spain) | gen CMKBR5 |
| it-IT | Italian (Italy) | CMKBR5, gene Synonyms: Gene CMKBR5 |
| tr-TR | Turkish (Turkey) | CMKBR5 geni |
| ru-RU | Russian (Russian Federation) | CMKBR5 ген |
| nl-NL | Dutch (Netherlands) | CMKBR5-gen Synonyms: CMKBR5 gen |
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