LP19680-5
CCR5 gene
Active
Description
The CCR5 gene (chemokine (C-C motif) receptor 5 (gene/pseudogene)) [HGNC Gene ID:1606] is located on chromosome 3p21.31. This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] [NCBI Gene ID:1234] Source: National Center for Biotechnology Information (NCBI) Gene
Reference Information
| Type | Source | Reference |
|---|---|---|
| Webcontent | Online Mendelian Inheritance in Man®Copyright OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University. | Link to OMIM |
Basic Part Properties
- Part Display Name
- CCR5 gene
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2000-05-04
- Construct for LOINC Short Name
- CCR5 gene
LOINC Terminology Service (API) using HL7® FHIR® Get Info
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- CodeSystem lookup
- https:
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | CCR5 基因 Synonyms: CCCKR5; |
| et-EE | Estonian (Estonia) | CCR5 geen |
| es-ES | Spanish (Spain) | Gen CCR5 |
| it-IT | Italian (Italy) | CCR5, gene Synonyms: Gene CCR5 |
| tr-TR | Turkish (Turkey) | CCR5 geni |
| ru-RU | Russian (Russian Federation) | CCR5 ген |
| nl-NL | Dutch (Netherlands) | CCR5-gen Synonyms: CCR5 gen |
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