Version 2.78

Description

The HRAS gene (Harvey rat sarcoma viral oncogene homolog) [HGNC Gene ID:5173] is located on chromosome 11p15.5. This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene. [provided by RefSeq, Jul 2008] [NCBI Gene ID:3265] Source: National Center for Biotechnology Information (NCBI) Gene

Reference Information

Type Source Reference
Webcontent Online Mendelian Inheritance in Man®Copyright OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University. Link to OMIM

Basic Part Properties

Part Display Name
HRAS gene
Part Type
Component (Describes the core component or analyte measured)
Created On
2000-05-04
Construct for LOINC Short Name
HRAS gene

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Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) HRAS 基因
Synonyms: Harvey 大鼠肉瘤病毒原癌基因;Harvey 大鼠肉瘤病毒癌基因;Harvey 大鼠肉瘤病毒致癌基因;HRAS1;v-Ha-ras 病毒原癌基因同源基因假基因;v-Ha-ras 病毒原癌基因同源基因拟基因;v-Ha-ras 病毒性原癌基因同源基因假基因;v-Ha-ras 病毒性原癌基因同源基因拟基因;v-Ha-ras 病毒性癌基因同源基因假基因;v-Ha-ras 病毒性癌基因同源基因拟基因;v-Ha-ras 病毒性致癌基因同源基因假基因;v-Ha-ras 病毒性致癌基因同源基因拟基因;v-Ha-ras
et-EE Estonian (Estonia) HRAS geen
es-ES Spanish (Spain) Gen HRAS
it-IT Italian (Italy) HRAS, gene
Synonyms: Gene HRAS
tr-TR Turkish (Turkey) HRAS geni
ru-RU Russian (Russian Federation) HRAS ген
nl-NL Dutch (Netherlands) HRAS-gen
Synonyms: HRAS gen