LP19745-6
MXI1 gene
Active
Description
The MXI1 gene (MAX interactor 1, dimerization protein) [HGNC Gene ID:7534] is located on chromosome 10q24-q25. Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally. [provided by RefSeq, Jul 2008] [NCBI Gene ID:4601] Source: National Center for Biotechnology Information (NCBI) Gene
Reference Information
| Type | Source | Reference |
|---|---|---|
| Webcontent | Online Mendelian Inheritance in Man®Copyright OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University. | Link to OMIM |
Basic Part Properties
- Part Name
- MXI1 gene
- Part Display Name
- MXI1 gene
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2000-05-04
- Construct for LOINC Short Name
- MXI1 gene
LOINC Terminology Service (API) using HL7® FHIR® Get Info
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- CodeSystem lookup
- https:
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | MXI1 基因 Synonyms: MAD2; |
| et-EE | Estonian (Estonia) | MXI1 geen |
| es-ES | Spanish (Spain) | Gen MXI1 |
| it-IT | Italian (Italy) | MXI1, gene Synonyms: Gene MXI1 |
| tr-TR | Turkish (Turkey) | MXI1 geni |
| ru-RU | Russian (Russian Federation) | MXI1 ген |
| nl-NL | Dutch (Netherlands) | MXI1-gen Synonyms: MXI1 gen |
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