LP19776-1
BCL6 gene rearrangements
Active
Descriptions
The protein encoded by the BCL6 gene arrangements is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. Source: National Center for Biotechnology Information (NCBI) Gene, BCL6 gene rearrangements
The BCL6 gene (B-cell CLL/lymphoma 6) [HGNC Gene ID:1001] is located on chromosome 3q27. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Sep 2008] [NCBI Gene ID:604] Source: National Center for Biotechnology Information (NCBI) Gene
Reference Information
| Type | Source | Reference |
|---|---|---|
| Webcontent | Online Mendelian Inheritance in Man®Copyright OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University. | Link to OMIM |
Basic Part Properties
- Part Display Name
- BCL6 gene rearrangements
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2000-05-04
- Construct for LOINC Short Name
- BCL6 gene Rear
LOINC Terminology Service (API) using HL7® FHIR® Get Info
Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.
- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=LP19776-1
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | BCL6 基因重排 Synonyms: BCL6 基因重排（重组）; |
| et-EE | Estonian (Estonia) | BCL6 geeni muudatused |
| es-ES | Spanish (Spain) | Reordenamientos del gen BCL6 |
| it-IT | Italian (Italy) | BCL6, riarrangiamenti gene Synonyms: Riarrangiamenti gene BCL6 |
| tr-TR | Turkish (Turkey) | BCL6 geni yeniden düzenlenmeler |
| ru-RU | Russian (Russian Federation) | BCL6 ген перестройки |
| nl-NL | Dutch (Netherlands) | BCL6-genherschikking Synonyms: BCL6 gen translocaties |
LOINC Copyright
Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright