Version 2.77

Description

Monomeric prolactin is the most common form of circulating prolactin. Prolactin also has several isoforms, including the dimeric form ("big-prolactin") that has a molecular weight of ~50 kD and polymeric form ("big-big prolactin") that has a molecular weight of ~ 150 kD). Big-big prolactin, known as macroprolactin, and big prolactin are formed in the circulation after secretion of prolactin from the pituitary. They have a longer half-life than monomeric prolactin are not biologically active. However, typical prolactin assays do not differentiate between the different forms of prolactin, and the presence of big and big-big prolactin can lead to a false diagnosis of hyperprolactinemia. Methods such as PEG precipitation can separate macroprolactin and big prolactin from monomeric prolactin in order to obtain a more accurate measurement of biologically active prolactin, and chromatography can be used to further characterize the isoforms if necessary. PMCID: PMC3719302 Source: Regenstrief LOINC,

Basic Part Properties

Part Display Name
Prolactin.dimeric
Part Type
Component (Describes the core component or analyte measured)
Created On
2015-08-25
Construct for LOINC Short Name
Prolactin.dim

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP200141-2

Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) 催乳素.二聚体
Synonyms: 催乳素（PRL、促乳激素、促乳泌素、促乳素、催乳激素、泌乳激素、泌乳素）.二聚体（二聚物）
es-ES Spanish (Spain) Prolactina dimérica
it-IT Italian (Italy) Prolattina.dimerica
Synonyms: Prolattina dimerica
tr-TR Turkish (Turkey) Prolaktin.dimerik
nl-NL Dutch (Netherlands) prolactine.dimeer