LP20019-3

CD45

Active

Descriptions

Found on alll leukocytes. Absent on erythrocytes.
May be reduced/absent in ALL, Lymphoblastic lymphoma, large cell anaplastic lymphoma, immunoblastic lymphoma, plasma cell proliferations Source: Regenstrief Institute

In immunology, the CD45 antigen (CD stands for cluster of differentiation) is a protein which was originally called leukocyte common antigen.

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, CD45

Basic Part Properties

Part Name

CD45

Part Display Name

CD45

Part Type

Component (Describes the core component or analyte measured)

Created On

2000-05-08

Construct for LOINC Short Name

CD45

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CodeSystem lookup

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP20019-3

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LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.