LP20020-1

CD5

Active

Descriptions

Found on all normal, mature T-cells, most thymocytes, minor B-cell subset
Associated with B-cell CLL; Nodal small lymphocytic lymphoma; Mantle cell lymphoma; May be absent in peripheral T-cell lymphoma and plasmacytoid lymphoma; Most T-cell neoplasms Source: Regenstrief Institute

CD5 is a cluster of differentiation found on a subset of IgM secreting B cells called B-1 cells, and also on T cells. B1 B cells have limited diversity of their B Cell Receptor (BCR) due to their lack of the enzyme terminal deoxynucleotidyl transferase (TdT) and are potentially self-reactive. CD5 serves to mitigate activating signals from the BCR so that the B1 cells can only be activated by a very strong stimuli (such as bacterial proteins) and not by normal tissue proteins. CD5 was used as a T cell marker until mABs against CD3 were developed. In humans, the gene is located on the q arm of chromosome 11. CD72 serves as a ligand. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, CD5

Basic Part Properties

Part Name

CD5

Part Display Name

CD5

Part Type

Component (Describes the core component or analyte measured)

Created On

2000-05-08

Construct for LOINC Short Name

CD5

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CodeSystem lookup

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP20020-1

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LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.