LP200493-7

NADH:ubiquinone reductase

Active

Description

NADH:Ubiquinone reductase (EC 1.6.5.3), also known as mitochondrial complex I, catalyzes the first step of the mitochondrial electron transport chain: the oxidation of NADH with electron transfer to ubiquinone (Coenzyme Q, CoQ), which is a lipid-soluble electron carrier embedded in the lipid bilayer of the inner mitochondrial membrane. Complex I is also considered to be one of the main sites of reactive oxygen species production, which results from electron leaks that can release single electrons to oxygen and give rise to superoxide anion. PMID: 16828051 Complex I deficiency is associated with a wide range of clinical disorders, including Parkinson disease, macrocephaly with progressive leukodystrophy, nonspecific encephalopathy, hypertrophic cardiomyopathy, myopathy, liver disease, Leigh syndrome and Leber hereditary optic neuropathy . [OMIM: 252010] Source: Regenstrief LOINC , [PMID: 16828051]

Basic Part Properties

Part Name

NADH:ubiquinone reductase

Part Display Name

NADH:ubiquinone reductase

Part Type

Component (Describes the core component or analyte measured)

Created On

2015-09-26

Construct for LOINC Short Name

NADH ubiq red

LOINC Terminology Service (API) using HL7^® FHIR^® Get Info

Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.

CodeSystem lookup

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP200493-7

Language Variants Get Info

LOINC Copyright

Copyright © 2025 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.