LP20077-1
CD40
Active
Description
CD40 is a costimulatory protein found on antigen presenting cells and is required for their activation. The binding of CD154 (CD40L) on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects.
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
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Source: Wikipedia,
CD40
Basic Part Properties
- Part Name
- CD40
- Part Display Name
- CD40
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2000-05-08
- Construct for LOINC Short Name
- CD40
LOINC Terminology Service (API) using HL7® FHIR® Get Info
Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | CD40 Synonyms: Bp50 |
| es-ES | Spanish (Spain) | CD40 |
| it-IT | Italian (Italy) | CD40 |
| tr-TR | Turkish (Turkey) | CD40 |
| ru-RU | Russian (Russian Federation) | CD40 |
| nl-NL | Dutch (Netherlands) | CD40 |
| pl-PL | Polish (Poland) | CD40 Synonyms: CD40 |
| el-GR | Greek (Greece) | CD40 Synonyms: CD40 |
LOINC Copyright
Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://