Version 2.80

Description

L-serine (L-ser) is an amino acid that plays a central role in cellular proliferation and is the major source of one-carbon groups for the de novo synthesis of purine nucleotides and deoxythymidine monophosphate. L-ser is converted to D-ser by serine racemase. Altered CNS D-ser levels have been associated with a variety of neurologic conditions, including schizophrenia and Parkinson's disease. L-ser also plays a specific role in the CNS, and patients with defects of L-ser synthesis have significant neurological impairment. Two enzyme defects linked to L-ser synthesis have been discovered: 3-phosphoglycerate dehydrogenase (3-PGDH) deficiency and phosphoserine phosphatase (PSP) deficiency. Patients with 3-PGDH deficiency can have significant neurologic impairment, including congenital microcephaly and seizures associated with decreased white matter volume and myelination, and L-ser supplementation has been used to treat the seizures in this patient population. PSP deficiency has only been identified in one patient, whose symptoms also improved with L-ser treatment. PMID: 12534373 Source: Regenstrief LOINC ,

Basic Part Properties

Part Name
L-serine
Part Display Name
L-serine
Part Type
Component (Describes the core component or analyte measured)
Created On
2015-10-20
Construct for LOINC Short Name
L-serine

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP201662-6
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https://fhir.loinc.org/ConceptMap/$translate?system=http://loinc.org&code=LP201662-6

Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) L-丝氨酸
tr-TR Turkish (Turkey) L-serin
it-IT Italian (Italy) L-serina
es-ES Spanish (Spain) L-serina
nl-NL Dutch (Netherlands) L-serine
el-GR Greek (Greece) L-σερίνη
Synonyms: L-σερίνη