LP201662-6
L-serine
Active
Description
L-serine (L-ser) is an amino acid that plays a central role in cellular proliferation and is the major source of one-carbon groups for the de novo synthesis of purine nucleotides and deoxythymidine monophosphate. L-ser is converted to D-ser by serine racemase. Altered CNS D-ser levels have been associated with a variety of neurologic conditions, including schizophrenia and Parkinson's disease. L-ser also plays a specific role in the CNS, and patients with defects of L-ser synthesis have significant neurological impairment. Two enzyme defects linked to L-ser synthesis have been discovered: 3-phosphoglycerate dehydrogenase (3-PGDH) deficiency and phosphoserine phosphatase (PSP) deficiency. Patients with 3-PGDH deficiency can have significant neurologic impairment, including congenital microcephaly and seizures associated with decreased white matter volume and myelination, and L-ser supplementation has been used to treat the seizures in this patient population. PSP deficiency has only been identified in one patient, whose symptoms also improved with L-ser treatment. PMID: 12534373 Source: Regenstrief LOINC,
Basic Part Properties
- Part Name
- L-serine
- Part Display Name
- L-serine
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2015-10-20
- Construct for LOINC Short Name
- L-serine
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | L-丝氨酸 |
| es-ES | Spanish (Spain) | L-serina |
| it-IT | Italian (Italy) | L-serina |
| tr-TR | Turkish (Turkey) | L-serin |
| nl-NL | Dutch (Netherlands) | L-serine |
| fr-FR | French (France) | L-sérine |
| pl-PL | Polish (Poland) | L-seryna |
| el-GR | Greek (Greece) | L-σερίνη Synonyms: L-σερίνη |
LOINC Copyright
Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://