Version 2.77

Description

Dimethylarginines are endogenous analogues of L-arginine. N,N-dimethylarginine (also known as asymmetrical dimethylarginine or ADMA) and N,N'-dimethylarginine (symmetrical dimethylarginine or SDMA) both inhibit cellular L-arginine uptake, and ADMA also competitively inhibits nitric oxide (NO) synthases. ADMA is predominantly degraded by the enzyme dimethylarginine dimethylaminohydrolase, while SDMA is primarily excreted by the kidney. PMID: 25245031 ADMA and NO play a pivotal role in endothelial dysfunction, and elevated ADMA levels may be associated with a higher risk of cardiovascular disease. SDMA has not been associated with cardiovascular disease but correlates with both measured and estimated glomerular filtration rate and is a marker of renal function. PMID: 26021436 Source: Regenstrief LOINC,

Basic Part Properties

Part Display Name
N,N'-dimethylarginine
Part Type
Component (Describes the core component or analyte measured)
Created On
2015-10-21
Construct for LOINC Short Name
N,N'-dimethylarginine

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CodeSystem lookup
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Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) N,N'-二甲基精氨酸
Synonyms: N,N''-双甲基精氨酸
es-ES Spanish (Spain) N,N'-dimetilarginina
it-IT Italian (Italy) N,N'-dimetilarginina
tr-TR Turkish (Turkey) N,N'-dimetilarjinin
nl-NL Dutch (Netherlands) N,N'-dimethylarginine