Version 2.78

Description

Dihydropyrimidine dehydrogenase (DPD, encoded by the DPYD gene; [HGNC Gene ID: 3012]) is the rate-limiting enzyme for fluoropyrimidine metabolism and is therefore responsible for the detoxification of these types of drugs. Patients who are homozygous for variants in DPYD that lead to a non-functional protein have a high risk of severe or fatal drug toxicities and may benefit from receiving an alternative chemotherapeutic drug. Patients heterozygous for these variants also have an increased risk for drug toxicities, and reduced dosing is recommended for these individuals. PMID: 23988873 See https://www.pharmgkb.org/gene/PA145 for more information and dosing guidelines for drugs impacted by DPYD genetic variation. Source: Clinical Pharmacogenetics Implementation Consortium

Basic Part Properties

Part Display Name
DPYD gene product metabolic activity interpretation
Part Type
Component (Describes the core component or analyte measured)
Created On
2015-11-09
Construct for LOINC Short Name
DPYD gene prod met act imp

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP202927-2

Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) DPYD 基因产物新陈代谢活性解释
Synonyms: DPYD 基因产物新陈代谢（代谢）活性解释（说明、阐释、诠释、解释说明）
es-ES Spanish (Spain) Gen DPYD interpretation de la actividad en el metabolismo de fármacos
it-IT Italian (Italy) DPYD, gene, interpretazione dell'attività metabolica
Synonyms: Interpretazione dell''attività metabolica del gene
tr-TR Turkish (Turkey) DPYD geni ürünü metabolik aktivite yorumu
nl-NL Dutch (Netherlands) DPYD-gen product metabole activiteit interpretatie
Synonyms: DPYD gen product metabole activiteit interpretatie