Version 2.80

Description

Solute carrier organic anion transporter family member 1B1 is a protein that in humans is encoded by the SLCO1B1 gene [HGNC Gene ID: 2645]. Variations in the SLCO1B1 gene have been significantly associated with a marked increase in systemic exposure to simvastatin and risk of muscle toxicity. PMID: 24918167 The overall effect size and significance of this association are striking for simvastatin compared to other statins. Patients with variations in SLCO1B1 (a transporter of simvastatin) may require a lower simvastatin dose or an alternative statin as compared to patients who do not have this variant. See https://www.pharmgkb.org/gene/PA134865839 for more information and dosing guidelines for drugs impacted by SLCO1B1 genetic variation. Source: Clinical Pharmacogenetics Implementation Consortium

Basic Part Properties

Part Name
SLCO1B1 gene product functional interpretation
Part Display Name
SLCO1B1 gene product functional interpretation
Part Type
Component (Describes the core component or analyte measured)
Created On
2015-11-09
Construct for LOINC Short Name
SLCO1B1 gene prod fnc imp

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP202928-0

Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) SLCO1B1 基因产物功能解释
Synonyms: SLCO1B1 基因产物功能（功能性、功能活性）解释（说明、阐释、诠释、解释说明）
tr-TR Turkish (Turkey) SLCO1B1 geni ürünü fonksiyonu yorumu
es-ES Spanish (Spain) Gen SLCO1B1 interpretación de la función del fármaco
it-IT Italian (Italy) Interpretazione funzionale del gene SLCO1B1
nl-NL Dutch (Netherlands) SLCO1B1-gen product functionele interpretatie
Synonyms: SLCO1B1 gen product functionele interpretatie
el-GR Greek (Greece) Λειτουργική ερμηνεία προϊόντος γονιδίου SLCO1B1
Synonyms: Λειτουργική ερμηνεία προϊόντος γονιδίου SLCO1B1