LP203038-7
HLA-A*31:01
Active
Description
The human leukocyte antigen B (HLA-B; [HGNC Gene ID: 4932]) plays an important role in how the immune system recognizes and responds to pathogens. HLA-B belongs to a class of molecules that are found on the surface of most cells. These molecules are responsible for presenting peptides to immune cells. Peptides derived from normal human proteins are recognized as such, whereas foreign peptides derived from pathogens trigger an immune response. Antiepileptics with an aromatic ring, for example carbamazepine and phenytoin, interact with HLA-B*31:01 and alter the repertoire of self peptides that are presented to T lymphocytes, which activates an immune reaction known as Stevens-Johnson syndrome or toxic epidermal necrolysis. PMID: 23695185 PMID: 25099164 See https://www.pharmgkb.org/gene/PA35056 for more information and dosing guidelines for drugs impacted by HLA-B genetic variation. Source: Clinical Pharmacogenetics Implementation Consortium
Basic Part Properties
- Part Display Name
- HLA-A*31:01
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2015-11-12
- Construct for LOINC Short Name
- HLA-A*31:01
LOINC Terminology Service (API) using HL7® FHIR® Get Info
Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.
- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=LP203038-7
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | HLA-A*31: Synonyms: 人类白细胞抗原; |
| es-ES | Spanish (Spain) | HLA-A*31: |
| it-IT | Italian (Italy) | HLA-A*31: |
| tr-TR | Turkish (Turkey) | HLA-A*31: |
| nl-NL | Dutch (Netherlands) | HLA-A*31: |
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