LP203040-3
TPMT gene product metabolic activity interpretation
Active
Description
Thiopurine S-methyltransferase (TPMT; [HGNC Gene ID: 12014]) is involved in the metabolism of all thiopurines and is one of the main enzymes that inactivates thiopurine drugs (e.g., Thioguanine, mercaptopurine, azathioprine). In all patients receiving thiopurine, there is a risk of bone marrow suppression. This adverse effect is dose-dependent and may be reversed by reducing the dose of thiopurine. However, individuals who inherit two no function TPMT alleles universally experience life-threatening myelosuppression. PMID: 23422873 See https://www.pharmgkb.org/gene/PA356 for more information and dosing guidelines for drugs impacted by TPMT genetic variation. Source: Clinical Pharmacogenetics Implementation Consortium
Basic Part Properties
- Part Display Name
- TPMT gene product metabolic activity interpretation
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2015-11-12
- Construct for LOINC Short Name
- TPMT gene prod met act imp
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- CodeSystem lookup
- https:
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | TPMT 基因产物新陈代谢活性解释 Synonyms: TPMT 基因产物新陈代谢（代谢）活性解释（说明、 |
| es-ES | Spanish (Spain) | Gen TPMT interpretation de la actividad en el metabolismo de fármacos |
| it-IT | Italian (Italy) | Interpretazione dell'attività metabolica del gene TPMT |
| tr-TR | Turkish (Turkey) | TPMT geni ürünü metabolik aktivite yorumu |
| nl-NL | Dutch (Netherlands) | TPMT-gen product metabole activiteit interpretatie Synonyms: TPMT gen product metabole activiteit interpretatie |
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