LP207901-2
GRN gene
Active
Description
The GRN gene (granulin) [HGNC Gene ID:4601] is located on chromosome 17q21.32. Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq, Jul 2008] [NCBI Gene ID:2896] Source: National Center for Biotechnology Information (NCBI) Gene
Basic Part Properties
- Part Name
- GRN gene
- Part Display Name
- GRN gene
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2016-02-28
- Construct for LOINC Short Name
- GRN
LOINC Terminology Service (API) using HL7® FHIR® Get Info
Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.
- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=LP207901-2
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| it-IT | Italian (Italy) | GRN, gene Synonyms: Gene GRN |
| zh-CN | Chinese (China) | GRN 基因 Synonyms: 颗粒体蛋白; |
| es-ES | Spanish (Spain) | Gen GRN |
| nl-NL | Dutch (Netherlands) | GRN-gen Synonyms: GRN gen |
| el-GR | Greek (Greece) | Γονίδιο GRN Synonyms: Γονίδιο GRN |
LOINC Copyright
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