LP20810-5
Eosinophil cationic protein
Active
Descriptions
ECP may reflect the rate of activation of circulating eosinophils Source: Regenstrief Institute
One of several basic proteins released from EOSINOPHIL cytoplasmic granules. Eosinophil cationic protein is a 21-kDa cytotoxic peptide with a pI of 10.9. Although eosinophil cationic protein is considered a member of the RNAse A superfamily of proteins, it has only limited RNAse activity. Source: National Library of Medicine, MeSH 2006
Eosinophils are the cells chiefly responsible for producing the inflammation associated with asthma. When eosinophils in the airway are activated, they undergo degranulation causing airway epithelial damage. This can lead to chronic inflammatory disease of the airway.
Asthmatic patients with eosinophilic inflammation have elevated levels of ECP in serum and other body fluids such as bronchial alveolar fluid and (induced) sputum. A high level of serum ECP indicates inflammation, which is a risk factor for asthmatic patients.
Asthma therapy consists of suppressing chronic and persistent airway inflammation. Measuring ECP in a serum sample is an objective and direct way of estimating the severity of the airway inflammation and following the course of the disease.
ECP serum measurements can be used:
•For monitoring inflammation in asthma
•For guiding corticosteroid treatment in asthma
•To find non-compliant patients
Copyright Copyright © 2006 Phadia AB.
Source: ImmunoCap, ImmunoCap
Basic Part Properties
- Part Display Name
- Eosinophil cationic protein (ECP)
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2000-07-11
- Construct for LOINC Short Name
- ECP
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 嗜酸性粒细胞阳离子蛋白 |
| fr-CA | French (Canada) | Protéine cationique des éosinophiles |
| et-EE | Estonian (Estonia) | Eosinofiilsete leukotsüütide katioonne proteiin |
| es-ES | Spanish (Spain) | Proteína catiónica eosinofílica (PCE) |
| it-IT | Italian (Italy) | Eosinofili, proteina cationica Synonyms: Proteina cationica degli eosinofili (ECP) |
| tr-TR | Turkish (Turkey) | Eozinofil katyonik protein |
| ru-RU | Russian (Russian Federation) | Эозинофилов катионный протеин Synonyms: Катионный протеин эозинофилов |
| nl-NL | Dutch (Netherlands) | eosinofiel kationisch eiwit Synonyms: ribonuclease 3; |
| fr-BE | French (Belgium) | Protéine cationique des éosinophiles |
| pl-PL | Polish (Poland) | Eozynofilowe białko kationowe Synonyms: Eozynofilowe białko kationowe (ECP) |
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