LP208404-6
TPP1 gene
Active
Description
The TPP1 gene (tripeptidyl peptidase I) [HGNC Gene ID:2073] is located on chromosome 11p15. This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome. [provided by RefSeq, Jul 2008] [NCBI Gene ID:1200] Source: National Center for Biotechnology Information (NCBI) Gene
Basic Part Properties
- Part Name
- TPP1 gene
- Part Display Name
- TPP1 gene
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2016-03-17
- Construct for LOINC Short Name
- TPP1
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | TPP1 基因 Synonyms: EC 3.4.14.9; |
| es-ES | Spanish (Spain) | Gen TPP1 |
| it-IT | Italian (Italy) | Gene TPP1 |
| nl-NL | Dutch (Netherlands) | TPP1-gen Synonyms: TPP1 gen |
| fr-FR | French (France) | TPP1 gène |
| pl-PL | Polish (Poland) | TPP1 gen Synonyms: Gen TPP1 |
| el-GR | Greek (Greece) | Γονίδιο TPP1 Synonyms: Γονίδιο TPP1 |
LOINC Copyright
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