LP208546-4
SDHB & SDHC & SDHD gene
Active
Description
Succinate dehydrogenase (SDH) is a mitochondrial enzyme complex made up of 4 subunits: subunit A (SDHA), subunit B (SDHB), subunit C (SDHC), and subunit D (SDHD). Mutations in the SDHB, SDHC, or SDHD genes are associated with pheochromocytoma (PHEO) and paraganglioma (PGL) syndromes. PMID: 17102077 To date, mutations in SDHA have not been associated with PHEO or PGL syndromes. Patients with a heterozygous mutation have only one functioning copy of the affected SDH subunit gene. When the second copy is somatically lost or mutated, tumors develop in tissues. Germline mutations in the SDHB, SDHC, and SDHD genes have been found in the majority of familial head and neck paraganglioma (HNPs) as well as in sporadic cases. PMID: 17102086 Source: Regenstrief LOINC
Basic Part Properties
- Part Name
- SDHB & SDHC & SDHD gene
- Part Display Name
- SDHB and SDHC and SDHD gene
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2016-03-23
- Construct for LOINC Short Name
- SDHB+SDHC+SDHD
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | SDHB 与 SDHC 与 SDHD 基因 Synonyms: SDHB & SDHC & SDHD 基因 |
| es-ES | Spanish (Spain) | Gen SDHB+SDHC+SDHD |
| it-IT | Italian (Italy) | SDHB & SDHC & SDHD, gene Synonyms: Gene SDHB e SDHC e SDHD |
| nl-NL | Dutch (Netherlands) | SDHB & SDHC & SDHD-gen Synonyms: SDHB & SDHC & SDHD gen |
| fr-FR | French (France) | SDHB et SDNC et SDHD gène |
| pl-PL | Polish (Poland) | SDHB & SDHC & SDHD gen Synonyms: Gen SDHB, SDHC i SDHD |
| el-GR | Greek (Greece) | Γονίδιο SDHB & SDHC & SDHD Synonyms: Γονίδιο SDHB & SDHC & SDHD |
LOINC Copyright
Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://