LP208566-2

F11 gene

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Description

The F11 (coagulation factor XI) gene [HGNC Gene ID: 3529] is located on chromosome region 4q35. This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality. [provided by RefSeq, Jul 2008][NCBI Gene ID: 2160] Source: National Center for Biotechnology Information (NCBI) Gene

Basic Part Properties

Part Name

F11 gene

Part Display Name

F11 gene

Part Type

Component (Describes the core component or analyte measured)

Created On

2016-03-24

Construct for LOINC Short Name

F11

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