LP208569-6

RAF1 gene

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Description

The RAF1 (Raf-1 proto-oncogene, serine/threonine kinase) gene [HGNC Gene ID: 9829] is located on chromosome 3p25. This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.[provided by RefSeq, Jul 2008][NCBI Gene ID: 5891] Source: National Center for Biotechnology Information (NCBI) Gene

Basic Part Properties

Part Name

RAF1 gene

Part Display Name

RAF1 gene

Part Type

Component (Describes the core component or analyte measured)

Created On

2016-03-25

Construct for LOINC Short Name

RAF1

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